Current Progress in Production of Building-Block Organic Acids by Consolidated Bioprocessing of Lignocellulose

Several organic acids have been indicated among the top value chemicals from biomass. Lignocellulose is most attractive feedstocks for biorefining processes owing to its high abundance and low cost. However, highly complex nature recalcitrance biodegradation hinder development of cost-competitive fermentation processes. Here, current progress in single-pot (i.e., consolidated bioprocessing, CBP) lignocellulosic biomass will be examined, based on potential this approach dramatically reduce process costs. Different strategies CBP considered such as: (i) design microbial consortia consisting (hemi)cellulolytic valuable-compound producing strains; (ii) engineering microorganisms that combine biomass-degrading high-value compound-producing properties a single strain. The present review mainly focus production with application as building block (e.g., adipic, cis,cis-muconic, fumaric, itaconic, lactic, malic, succinic acid) since polymer synthesis constitutes largest sector chemical industry. Current research advances illustrated together challenges perspectives future investigations. In addition, attention dedicated acid tolerant microorganisms, an essential feature improving titer productivity fermentative acids.